On January 31, 2006, it was nominated for the Academy Award for Best Animated Short Film, but lost to The Moon and the Son: An Imagined Conversation by John Canemaker and Peggy Stern. It was included in the Animation Show of Shows in 2005.
The film premiered on June 11, 2005, at the Annecy International Animated Film Festival in Annecy, France. It was shown with the theatrical release of Cars, which was released in the United States on June 9, 2006.
The Allman Brothers Band is a Hall of Fame American Rock band formed in Jacksonville, Florida in 1969, which blended different forms of southern Rock- Blues, Jazz, Gospel and more. A very \"Jam\" oriented band, they rocked shows well into the 2000s! We have one of their tour tees from 2005, get it while its here!
Elective esophageal variceal ligation (EVL) is performed to decrease the risk of variceal hemorrhage. Side effects of EVL include hemorrhage, chest pain, dysphagia, and odynophagia. Because gastric acid may exacerbate postbanding ulcers and delay healing, proton pump inhibition may decrease side effects associated with EVL. The aim of this study was to assess the efficacy of pantoprazole, a proton pump inhibitor, as an adjunct to elective EVL. We performed a double-blinded, randomized, placebo-controlled trial of pantoprazole after elective EVL. Subjects in the pantoprazole arm received 40 mg pantoprazole intravenously after EVL followed by 40 mg oral pantoprazole for 9 days. Control subjects received intravenous and oral placebo. Subjects underwent upper endoscopy 10 to 14 days after banding. Primary outcomes included the size and number of ulcers and the subjects' reports of dysphagia, chest pain, and heartburn. Forty-four subjects were randomized: 42 completed the protocol. At follow-up endoscopy, the mean number of ulcers was similar in the two groups. However, the ulcers in the pantoprazole group were on average half as large as in the placebo group (37 mm(2) vs. 82 mm(2), P < .01). Chest pain, dysphagia, and heartburn scores were not significantly different. Four subjects, all in the placebo group, had adverse outcomes, including 3 who bled from postbanding ulcers and 1 with sepsis. In conclusion, subjects receiving pantoprazole after elective EVL had significantly smaller postbanding ulcers on follow-up endoscopy than subjects receiving placebo. However, the total ulcer number and patient symptoms were not different between the groups.
Throughout its illustrious 45-year career, the ALLMAN BROTHERS BAND has played many legendary venues and widely praised live shows. However, up until this point, the sold-out show on July 19, 2005 at the Warner Theatre in Erie, Pennsylvania hasn't been included on that list. Long hailed as one of their best ever by the band members themselves, on October 16 fans will have the opportunity to experience this spectacular show for themselves with the commercial release of a 2-CD set via Allman Brothers Band Recording Company, distributed by The Orchard.
The 2005 tour was a typical ALLMAN BROTHERS BAND run of festival and amphitheater shows, with a sprinkling of casino and theater appearances thrown in along the way, Warner Theatre being one of them. In the weeks leading up to this show, the band had traveled a great deal with long drives and performed three shows in a row before arriving in Erie early on July 18, a much-needed day off. The band came into this show rested and ready to turn things up for the last five shows of the run.
A major ingredient to the success of this night was the meticulously crafted setlist from Warren Haynes, with input from the other members. Since this was one of a few \"Evening with\" theater shows, and was to be a two-set show with intermission and no opening act, this gave the band room to stretch and set the tone differently from an amphitheater show. With the recent release of 2003's \"Hittin' The Note\", there was a lot of new material to pull from as well as exceptional new covers which had recently been brought into the fold (\"The Night They Drove Old Dixie Down\" and \"Don't Think Twice, It's All Right\", with guesting vocalist Susan Tedeschi). The group kicked things off with rare show-opener \"Mountain Jam\" and it was evident that the band was firing on all cylinders, right from the jump.
The year 2005 saw World Music grow in two directions: by exploring its most basic roots, and by exploring new areas, through technology and collaboration. Marco Werman give us a glimpse of his top picks of the year.
Intrathecal synthesis of IgG antibodies in the form of oligoclonal bands (OCB) occurs in both, patients with MS and CIS . The presence of OCB in patients with CIS is considered to be a prognostic marker for developing MS [10,11]. The correlation between the OCB status in MS patients and the disease course is controversially discussed. Some studies reported that MS patients without OCB have a slower disease progression, and thus, a better long-term prognosis .
OCB restricted to the CSF were found in all but five patients (96%) indicating intrathecal IgG synthesis. Ten of these patients showed a combination of OCB exclusively in the CSF plus identical OCB in CSF and serum (type 3). Only one patient showed a weak OCB pattern with only three CSF bands.
OCB restricted to the CSF were found in 104 patients (55%). Nine of these patients showed a combination of OCB restricted to the CSF and identical oligoclonal IgG bands in CSF and serum (type 3). Five patients with CSF OCB showed weak values with two or three CSF bands (type 2a or 3a).
It has been claimed that the McDonald criteria revisions of 2010 in some instances will allow a more rapid diagnosis of MS with equivalent or improved specificity and/or sensitivity compared with the previous criteria and will clarify and simplify the diagnostic procedure with fewer MRI examinations . Our data agree with these expectations. While only 70 of 325 patients (22%) could be designated as MS according to the McDonald criteria of 2005, the number of newly diagnosed MS almost doubled to 136 patients (42%) in the same cohort, when the new criteria of 2010 were applied. Most importantly this remarkable increase in clinical sensitivity reduced the prevalence of OCB only marginal which dropped slightly from 98.5% to 96%.
Considering the fact that more MS patients can be diagnosed in an early stage of the disease, the new criteria have achieved their goal. However, a word of caution might be indicated. While only one patient lacked OCB in the 70 patients classified as MS according to the McDonald criteria of 2005/2001, this number rose to 5 of 136 patients, when the new criteria of 2010 were applied. A conversion to OCB positivity has been described in follow-up CSF investigations in about 50% of MS patients with initial absence of OCB . Furthermore, Davies and colleagues reported that 9 of 27 patients showing a monoclonal band in IEF at the first lumbar puncture developed a clear oligoclonal response over a 6-year follow-up period, indicating a propensity for an inflammatory autoimmune driven CNS disease . In our opinion a second lumbar puncture would be desirable to identify patients who develop OCB in the course of disease: on the one hand to obtain additional evidence supporting the diagnosis MS and on the other hand to identify patients with negative OCB as patients without OCB are considered to have a benign prognosis [9,17]. Repeated MRI and re-examination of the CSF were already suggested by others for OCB negative MS patients . The German Society for Neurology suggests a control lumbar puncture after one year. Nevertheless, a low number of clinically definitive MS patients remain persistently OCB negative [9,17].
Another important aspect is the prevalence of OCB in patients diagnosed with CIS. Since more patients were diagnosed with MS according to the latest McDonald criteria the group of patients diagnosed with CIS decreased substantially from 255 patients (McDonald 2005) to 189 patients (McDonald 2010). As expected the prevalence of OCB in the 189 CIS patients was lower with 55% when compared to patients diagnosed with CIS according to the previous McDonald criteria of 2005/2001 with 65%, which compares well to the 68.6% in the meta-analysis of Dobson and colleagues .
But health and environmental officials have been slow to act on the wealth of studies on childhood vulnerability produced in the past 20 years. After nearly a decade of review, the Environmental Protection Agency updated its cancer risk guidelines in 2003 to explicitly acknowledge the importance of childhood exposures. The agency concluded, after a review of 23 studies of early life exposures to cancer-causing chemicals, that carcinogens average 10 times the potency for babies than adults, and that some chemicals are up to 65 times more powerful (EPA 2005a).
Over the past 50 years, as infectious childhood diseases like polio, smallpox, rheumatic fever, and diphtheria have largely been controlled, chronic conditions of less obvious origins have taken their place. Asthma, autism, attention deficit and hyperactivity disorders (ADD and ADHD), childhood brain cancer and acute lymphocytic leukemia have all increased over the past 30 years. Five to ten percent of American couples are infertile. Up to half of all pregnancies end in miscarriage. Three to five percent of babies are born with birth defects (CDC 2004, Jahnke et al. 2005, Trasande and Landrigan 2004). Scientists cannot fully explain these increases, but early life exposure to environmental pollutants is a leading suspect.
Laboratory studies show increased deposits of the Alzheimer-related protein amyloid in the brains of older animals exposed to lead as newborns, but not in animals that were exposed to an equal amount of lead as adults (Basha et al. 2005). And over the past two decades numerous studies have linked low birth weight with adult onset of coronary heart disease, diabetes, stroke, hypertension, depression and other conditions (Barker 1995, Wahlbeck et al. 2001, Thompson et al. 2001, Hales et al. 1991). Low birth weight can arise not only from poor maternal nutrition but also from a host of industrial pollutants, including arsenic, mercury, lead, organic solvents, PCBs, and pesticides, including DDT. 59ce067264